Sam and Dean are cornered by demons, but saved at the last minute by Rob and his townspeople, who are aware of the Apocalypse and have been training to fight and kill demons. The small town is very religious, and the brothers meet Pastor Gideon, who introduces them to his daughter Leah. She has been the one supposedly receiving visions from angels and guiding the townspeople to demons, whom the townspeople always seem to defeat. Eventually Leah begins telling the locals that the angels are giving her the names of the "evil" citizens among them. The brothers learn that Leah has been taken over by Whore of Babylon, a creature from Hell that emerges during the Apocalypse and tries to condemn as many people as possible to eternal punishment in Hell by tricking them into committing Deadly Sins.
The Whore had only been sending locals on demon hunting trips to earn their trust. Her true agenda is to kill as many of the townspeople as she can with the help of select acolytes whom she now controls, and damn the souls of the rest to Hell. She can only be killed with a special wooden stake made in Babylon and by the hand of a true servant of Heaven. The Pastor has become concerned by Leah's increasingly ruthless behavior, and while walking outside is confronted by Sam and Dean who inform him of the truth. United with Castiel, they inform the Pastor that Leah is not his real daughter but the creature that killed her.
The demonic creature has to be killed and they point out that the Pastor is a true servant of Heaven. The halt the Whore just before she and her acolytes can burn the townspeople to death. The pastor is knocked out. The Whore begins battling Dean but he manages to stake her with the sacred staff, proving to a surprised Sam that he is a true servant of Heaven. Sam asks him if he is going to do something stupid like letting in Michael. In the end, Dean goes to meet Lisa and tells her that, in the next few days, she's going to see horrifying and unbelievable things on TV, but she needs not worry because he is going to make arrangements to protect her and her son, Ben. He also confesses that if he could, he would live his dream of having a happy family. Lisa is terrified and asks Dean to stay, have a beer and relax for a while, but Dean declines and leaves.
